G-quadruplex homeostasis is a determinant of PARP inhibitor toxicity in BRCA2-deficient cells
The DNA structures underlying PARP inhibitor toxicity in BRCA2-deficient cells remain unclear. Here, the authors identify G-quadruplex structures as determinants of PARP inhibitor sensitivity and find that the BRCA2 and HAPSTR1–HUWE1 pathways suppress G4s to ….
Scientists have detected a giant fan-shaped structure buried beneath the East Antarctic Ice Sheet, suggesting the frozen continent may be hiding the geological scars of the breakup that helped separate Antarctica from Australia
East Antarctica can look, from above, like the quiet half of the frozen continent: old, thick, cold and buried under kilometres of ice. But beneath that ice, new mapping suggests the bedrock may carry the shape of a much more violent past. In a Nature Geoscie….
De la opulență la supraviețuire. Cum încearcă Dubaiul să își reconstruiască mirajul după războiul cu Iranul
Înainte de izbucnirea conflictului cu Iranul, prin portul Jebel Ali treceau zilnic 40.000 de containere maritime. Complexul uriaș de dane și cheiuri de ape adânci a propulsat transformarea acestui emirat dintr-o așezare modestă într-o putere economică globală..
Los funerales de Alí Jamenei ponen a prueba el acuerdo con EEUU: Irán insta a Trump a contener los ataques de Israel
Teherán despedirá desde este sábado y durante seis días al líder supremo asesinado el 28 de febrero, en una ceremonia diseñada para exhibir la continuidad del régimen. Netanyahu amenaza mientras Trump se conforma. Más información: Trump ya no intimida: Omán ….
Indian markets saw a second day of gains, with the Nifty reclaiming its 100-day moving average, signaling a bullish trend. Key companies like Marico, Tata Motors PV, and Adani Enterprises are in focus due to strong Q1 updates and fundraising plans. PNB and Ba….
Startups focus on in-house manufacturing to exercise quality control, build competitive edge
D2C startups are bringing manufacturing in-house to gain greater control over product quality and inventory levels. Founders say owning factories enables faster product innovation, shorter lead times, higher margins and reduced dependence on third-party manuf….
IT stocks surged on Thursday, with the Nifty IT index climbing over 4.7% and leading gains on the NSE. This rebound followed recent losses, driven by a US tech rally and anticipation of quarterly results. Large-cap firms like Infosys and TCS saw significant j….
Cheaper oil, RBI support fail to lift rupee amid dollar demand
The Indian rupee weakened to 95.39 against the dollar on Thursday, despite lower oil prices and central bank support. Demand from foreign banks, oil firms, and investor outflows pressured the currency. Traders noted Reserve Bank of India intervention, partic….
Jewellers may be louped in for idle gold mobilisation
The government is exploring a revamped Gold Monetisation Scheme, aiming to involve jewellers for the first time to tap into the vast amount of household gold. This initiative seeks to reduce India's reliance on imported bullion, especially with gold prices an….
Stopped 8 wars: Donald Trump reiterates claim of India-Pakistan ceasefire through tariff threat
US President Donald Trump claimed he single-handedly averted a nuclear conflict between India and Pakistan by threatening both with 200% tariffs. He asserted this economic pressure stopped eight wars, including the India-Pakistan standoff following the April ….
Mojtaba Khamenei to skip his father, Ali Khamenei's, funeral over security concerns: Report
Iran's current Supreme Leader, Mojtaba Khamenei, will skip his father's funeral due to Israeli threats, according to a representative. This follows a stern warning from Iran's Foreign Minister to the US, urging them to control Israel after its Defence Ministe….
Mynd Fintech, part of Treds platform M1xchange, acquires C2FO India
M1xchange is an RBI-licensed Treds (Trade Receivables Electronic Discounting System) entity. C2FO runs C2Treds and also has the same licence, which it may surrender going ahead. C2FO India’s parent company Pollen Inc. (C2FO US) is a major global player in ear….
Our focus is data centres because they are big fibre guzzlers: Corning's Sudhir Pillai
Corning broke ground for a new optical connectivity manufacturing facility in Pune in February this year. The plant is being built alongside the company’s existing optical fibre facility, which has been operational since 2012. The company said the new facilit….
SEMABIZはMarketsandMarkets（マーケッツアンドマーケッツ）の英文調査報告書「農業機械市場規模、シェア、動向、2033年までの世界予測-Farm Equipment Market - Global Forecast to 2033」の販売を2026年7月3日に開始いたしました。株式会社SEMABIZはMarketsandMarketsの日本の正規代理店です。農業機械市場は、2026年....
From being a trust to gaining trust: AIFs call for switch to LLP model
India's private equity and venture capital sector is pushing for a crucial structural change to attract more foreign investment. The industry advocates for converting Alternative Investment Funds (AIFs) from trusts to Limited Liability Partnerships (LLPs), a ….
Jewellers may be louped in for idle gold mobilisation
The government is exploring a revamped Gold Monetisation Scheme, aiming to involve jewellers for the first time to tap into the vast amount of household gold. This initiative seeks to reduce India's reliance on imported bullion, especially with gold prices an….
Pre-market action: Here's the trade setup for today's session
Indian equities saw a positive close on Thursday, with the Nifty climbing 0.5% to 24,175. Analysts anticipate a gradual upward trend driven by favorable global sentiment and central banks' focus on inflation control. Stock-specific movements are expected from….
Collateral Damage: Proprietary traders feel the squeeze under RBI's new rules
New RBI rules demanding 100% collateral for bank guarantees from July 1 are set to significantly impact proprietary trading desks. These firms, crucial to market turnover, face increased funding costs and squeezed profits. Industry experts warn of reduced t….
Share live feed, need 24/7 vigil: Angry parents after Bengaluru tech campus creche horror
Shocking allegations of toddler abuse at a Bengaluru daycare, operating on Capgemini's campus, have ignited outrage among working parents. Demands for livestreamed activities and constant surveillance are surging. The incident highlights a critical lack of ov….
UAE Rewrites Offshore Oil Pricing To Capture Asian Markets
Previously, we reported that Abu Dhabi’s flagship crude, Murban crude, has rapidly risen to prominence, with Murban crude futures having rapidly evolved from a regional benchmark into a primary global pricing standard. Known for its high API gravity and low s….
War Drama ‘Peluru Senja: The Ghost & the Gun’ Locks Malaysia Theatrical Date, Drops Trailer (EXCLUSIVE)
The first trailer for “Peluru Senja: The Ghost & the Gun” has arrived alongside confirmation of a nationwide Malaysian theatrical release on Aug. 28, timed to the country’s Independence Day weekend. Local distributor MSK Cinemas will handle the rollout. The B….
NEIGRIHMS creates history with Eastern India’s first trans-catheter tricuspid valve repair
The Department of Cardiology at the North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS) has achieved a major milestone by successfully performing Eastern India’s first Trans-Catheter Tricuspid Valve Repair (TTVR), offerin….
By P.R. Pradhan The Rastriya Swatantra Party (RSP) held its first national convention in Chitwan last week. The party, established just before the 2022 general elections, won 20 seats in Parliament and secured an almost two-thirds majority in the March 5 elec….
