CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials
KMT2A-rearranged and NPM1-mutant acute leukemias treated with menin inhibitors frequently acquire resistance due to MEN1 mutations. Here, the authors use CRISPR base-editor screens to predict shared and drug-specific MEN1 resistance mutations across five clin….
Preguntan a Trump por los responsables del ataque mortífero contra la escuela de Minab y responde esto
El presidente de EE.UU. fue consultado sobre el bombardeo ocurrido durante el inicio de la ofensiva militar estadounidense-israelí contra Irán, que dejó más de un centenar de muertos, en su mayoría niñas..
SEBI plans major changes to buyback rules, seeks public comments
The regulator also suggested simplifying compliance norms, removing the mandatory appointment of merchant bankers, improving shareholder communication and ensuring companies do not violate minimum public shareholding rules.
Urban mobility is key to governance and ease of living, says CAG Murthy
At the 5th BRICS Supreme Audit Institutions Summit, delegates from nine countries discussed challenges such as congestion, rapid urbanisation and environmental stress, while highlighting sustainable transport, digital governance and data-driven audit systems.
RBI moots safeguards to curb digital payment fraud: How will they protect bank customers?
To curb digital payment fraud, the RBI has suggested measures such as lagged credit, a trusted person authenticating transactions for vulnerable individuals, prescribing a ceiling for annual aggregate credits in a bank account, and providing customer-induced ….
SC acquits man after 22 years in jail, raps Delhi high court for nixing delayed appeal
The Supreme Court has ordered the release of a murder convict after 22 years, criticizing the Orissa High Court for dismissing his appeal solely on grounds of delay. The apex court invoked its extraordinary powers under Article 142, highlighting the convict's….
Netflix, Disney+, Hulu, Paramount+, HBO Max new movies, series: 'Yellowstone' spinoff to 'The Crash', full list of films to watch this week
"Yellowstone" spinoff "Dutton Ranch" is set to return on Paramount+. Here are other films and series that can be streamed on Netflix, Disney+, Hulu, and HBO Max..
Accor raises its India play as domestic luxury demand reshapes hotels
Accor India's chairman Gaurav Bhushan said that the luxury hotel sector has significant growth potential. With a focus on domestic travellers, Accor plans to expand its portfolio to 300 hotels by 2030, capitalizing on the increasing demand for high-quality ho….
Trump administration appeals latest court defeat in battle over global tariffs
The Trump administration is appealing a court ruling that found its 10% global tariff, imposed under a 1970s trade law, was unjustified. The court blocked the tariffs for three specific importers, but the administration expects to prevail in the appeal. This ….
Tata Trusts have postponed crucial board meetings. The meetings were to discuss Tata Sons' potential public listing and board representation. Legal challenges and differing views among trustees are cited as reasons for the delay. The trusts are reinforcing th….
Britannia moves manufacturing to India amid West Asia crisis
Britannia has moved its North America export operations to Mundra and plans selective price hikes as fuel and packaging costs rise amid global disruptions..
Tata Consumer reshapes FMCG playbook around quick commerce, innovation and wellness
Tata Consumer is betting on quick commerce, wellness products and innovation-led growth as it targets strong FY27 performance with rising digital sales and margins..
Desarticulan tres estructuras del narcotráfico y crimen organizado; 42 capturados
El Ministerio Público (MP) presentó los resultados de una serie de operativos recientes que permitieron desarticular tres estructuras criminales dedicadas al narcotráfico y al crimen organizado.Es noticia. Las detenciones son parte de las acciones para combat….
Argel, el suma y sigue en el escándalo de la venta de visados para entrar en España tras Nador, Tánger y Orán
La Audiencia Nacional investiga una nueva red dedicada a facilitar papeles a cambio de dinero que luego blanqueaba con la compra de vehículos. Más información: Exteriores abre una investigación por la venta de visados en el Consulado de España en Tánger.
